CVE intelligence and bounded remediation

CVE-2025-50675 — GPMAW 14, a bioinformatics software, has a critical vulnerability related to insecure file permissions in its installation directory

High CVSS 7.8

GPMAW 14, a bioinformatics software, has a critical vulnerability related to insecure file permissions in its installation directory. The directory is accessible with full read, write, and execute permissions for all users, allowing unprivileged users to manipulate files within the directory, including executable files like GPMAW3.exe, Fragment.exe, and the uninstaller GPsetup64_17028.exe. An attacker with user-level access can exploit this misconfiguration by replacing or modifying the uninstaller (GPsetup64_17028.exe) with a malicious version. While the application itself runs in the user's context, the uninstaller is typically executed with administrative privileges when an administrator attempts to uninstall the software. By exploiting this flaw, an attacker could gain administrative privileges and execute arbitrary code in the context of the admin, resulting in privilege escalation.

Severity
High
CVSS
7.8 (3.1)
Published
2025-08-07
CISA KEV
Not currently listed
Ecosystem
software/application
Weaknesses
CWE-732

Affected products

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Matched remediation archetype

Privilege escalation and unsafe privilege management

This catalog composition supplies bounded fallback guidance. Explicitly reviewed curated workflows load with the complete record below.

Check exposure

  • Map service accounts, operating-system identities, roles, capabilities, impersonation, set-user transitions, and administrative helper paths.
  • Determine whether untrusted users or lower-privilege processes can reach the affected transition or modify inputs it trusts.
  • Review file, socket, registry, device, job, container, and cloud-role permissions used before and after privilege changes.

Remediate safely

  • Apply the supported fix and redesign privileged operations as a minimal, authenticated, allowlisted interface.
  • Drop privileges before processing untrusted input, verify the drop succeeds, and remove unnecessary roles, capabilities, and write permissions.
  • Validate ownership and permissions at time of use and add explicit lower-to-higher privilege boundary tests.

Authoritative sources

Complete CVE record and remediation plan

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