CVE intelligence and bounded remediation

CVE-2024-50636 — PyMOL security vulnerability

Critical CVSS 9.8

PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.

Severity
Critical
CVSS
9.8 (3.1)
Published
2024-11-11
CISA KEV
Not currently listed
Ecosystem
python/pypi
Weaknesses
CWE-94

Affected products

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Matched remediation archetype

Command, code, expression, and template injection

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Check exposure

  • Trace untrusted values to process execution, interpreters, evaluators, template engines, dynamic imports, and administrative scripting features.
  • Determine whether the affected path is reachable across each trust boundary and which service account or host privilege it inherits.
  • Review configuration for optional execution features, unsafe compatibility modes, and shell invocation.

Remediate safely

  • Replace string-built commands or evaluated code with fixed operations and structured argument APIs that do not invoke a shell.
  • Use strict allowlists for operation identifiers and reject unexpected input before it reaches any interpreter.
  • Update the affected component and add inert regression tests covering metacharacters, encoding variants, and alternate request paths.

Authoritative sources

Complete CVE record and remediation plan

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